AACC is hosting Pre-recorded Webinar on Understanding Findings of Sex-specific 99th Percentile URLs for High-sensitivity Cardiac Troponin Assays.
At The End of This Activity, Participants Will Be Able to:
- Identify sex-specific 99th percentiles variations according to the statistical method and hs-cTn assay used.
- Describe why not all assays provided measurable concentrations for women to qualify as hs assays.
- Summarize how and when surrogate exclusion criteria should be used to define normality.
Date: June 17, 2020
Time: 1 PM Eastern
Selection of healthy reference populations and definition of exclusion criteria for deriving 99th percentiles upper reference limits for high-sensitivity cardiac troponin assays (hs-cTn) used in clinical practice and research vary considerably. Dr. Fred S. Apple and Dr. W. Frank Peacock discuss the following Universal Sample Bank findings and their clinical implications:
- Sex-specific 99th percentiles varied according to the statistical method and hs-cTn assay used
- Not all assays provided measurable concentrations for women to qualify as hs assays
- Surrogate exclusion criteria used to define normality tended to lower 99th percentiles.
Participants will learn that the decision concentrations used can affect diagnostics, risk-outcome assessments, and analytical characteristics.